Does Menopur need mixing before injecting?

Some presentations need reconstituting with a diluent before use. Follow the leaflet in the box and the technique your clinic nurse showed you.

Does it need to be refrigerated?

This depends on the specific product and packaging, so check the patient information leaflet and your clinic's guidance.

What if injecting is painful?

Some people find Menopur stings more than other injections. Ask your clinic nurse about technique and timing, and mention persistent pain.

What happens if a dose is late?

Contact your clinic rather than adjusting the timing yourself, since monitoring during stimulation depends on consistent dosing.

Combined FSH and LH injection

Menopur

Also known as Menotrophin, Human menopausal gonadotrophin (hMG)

Written by Zayn Miah & R KhanomLast updated 17 September 2026Not clinically reviewed

Menopur contains a mixture of follicle stimulating hormone and luteinising hormone, extracted and purified from urine, given by injection under the skin or into muscle.

Why it may be used

It is used to stimulate the ovaries to develop multiple follicles during IVF, and some clinics prefer it, or a combination approach, because it includes LH activity alongside FSH.

Where it fits in a cycle

It is usually given during the ovarian stimulation phase of a cycle, sometimes alone and sometimes alongside another FSH medicine, with the plan set by your clinic and adjusted according to scan and blood test results.

Side effects listed in the patient leaflet

Injection site reactions such as redness, swelling or bruising
Headache
Abdominal pain or bloating
Nausea or vomiting
Breast tenderness
Mood swings or irritability
Ovarian enlargement during treatment

When to ring the clinic

•Rapid or severe abdominal swelling
•Severe abdominal or pelvic pain
•Shortness of breath
•Noticeably reduced urine output
•Sudden weight gain or signs of infection at the injection site

Questions people ask

Does Menopur need mixing before injecting?: Some presentations need reconstituting with a diluent before use. Follow the leaflet in the box and the technique your clinic nurse showed you.
Does it need to be refrigerated?: This depends on the specific product and packaging, so check the patient information leaflet and your clinic's guidance.
What if injecting is painful?: Some people find Menopur stings more than other injections. Ask your clinic nurse about technique and timing, and mention persistent pain.
What happens if a dose is late?: Contact your clinic rather than adjusting the timing yourself, since monitoring during stimulation depends on consistent dosing.

Safety

This information is general and educational, not a substitute for advice from your clinical team.
Follow the exact instructions your clinic has given you for this medicine, as protocols vary between patients.
The patient information leaflet in the box is the definitive source for storage, preparation and side effects.
Tell your clinic about any other medicines, allergies or health conditions before treatment begins.

Sources

Patient information leaflets and product characteristics, electronic medicines compendium (emc). Link checked 17 September 2026.
IVF: what is IVF and how does it work?, HFEA (UK fertility regulator). Link checked 17 September 2026.

Written by patients, not clinicians. This page has not yet been reviewed by a named fertility professional, so it explains published guidance and points you to the original source instead of giving medical advice. It is not medical advice. Decisions about your treatment belong with your own clinic. Read our editorial policy and corrections policy.