GnRH antagonist

Also written as short protocol drug

Written by Zayn Miah & R KhanomLast updated 17 September 2026Not clinically reviewed

A medication that quickly blocks the pituitary gland from releasing the hormone surge that triggers ovulation.

In plain English

It's a drug added partway through stimulation to stop you ovulating early, without the long build-up an agonist needs.

Why it matters

It's used in the 'antagonist protocol', a shorter route to egg collection with fewer injection days than the long protocol.

Related terms

Guides that cover this

Written by patients, not clinicians. This page has not yet been reviewed by a named fertility professional, so it explains published guidance and points you to the original source instead of giving medical advice. It is not medical advice. Decisions about your treatment belong with your own clinic. Read our editorial policy and corrections policy.